Aspartame Affects Magnesium




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"The doctor of the future will give no medicine, but will interest his patients in the care of the human frame, in diet and in the cause and prevention of disease."
- Thomas Edison

Cancer is a political problem more than it is a medical problem.

"Dr. Gross told Congress that aspartame violated the Delaney Amendment, which had forbid anything being put in food you knew would cause cancer, and this was because without a shadow of a doubt, aspartame can cause brain tumors."

"And if the FDA violates the law, who is left to protect the public?"

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RTM: Kovatsi & Tsouggas:
aspartame affects magnesium  Sept 2001  11.22.1 rmforall

Magnes Res 2001 Sep;14(3):189-94
The effect of oral aspartame administration on the balance of magnesium in the rat.
Kovatsi L, Tsouggas M.
Laboratory of Forensic Medicine & Toxicology, Faculty of Medicine
Aristotle University of Thessaloniki, Greece.

The aim of the present work was to determine the effect of aspartame administration on the excretion of magnesium and its distribution in the various rat tissues and organs. The present results have shown that aspartame administration influences the balance of magnesium in the organism, since in some organs and tissues (heart, lungs, kidneys, adrenals, jejunum, hair and blood) it is accumulated, while other organs (liver and testes) are deprived of it. Aspartame administration also affects the excretion of magnesium from the organism, since it decreases the concentration of magnesium in both urine and feces. PMID: 11599551

L. Kovatsi is co-author of three similarly highly technical studies, recently listed in PubMed, while M. Tsouggas has no other papers listed.

I have added, at the end of this post, some information to show that magnesium is a well developed research area. Of course, like virtually any aspect of medical research, it can be readily turned into health fraud, whether by corporate machinations or by the well known plethora of other quackeries.

Good scientists always always have in mind what they are trying to establish.  Better scientists welcome the process of having to change their minds in the face of obdurant evidence. So, as a layman, I regard it as significant that biochemists in Greece are examining the details of aspartame metabolism.  I'm guessing that they are laying some groundwork for establishing aspartame toxicity as a well recognized topic for research and medical practice.

We behold in the last three years the typical expansion of an evidence- based medical field, as detailed biochemical investigations and competent reports by eminent clinicians converge to establish the reality of aspartame toxicity.  As the decades-long campaign, well-funded, adroit, and very successful, by industry PR to cast the issue as a case of cranks and mistaken professionals assailing a completely innocent, beneficial product, "the most tested food additive in history," finally flounders in a stormy sea of public protest and stubborn facts, the current  meager trickle of research will fast become a mainstream effort, obviously credible and officially sanctioned, at last, for the enormous relief of completely gratuitous public misery. By no means a "food additive", "Generally Regarded As Safe", aspartame on the face of it is a potent drug, soon to be widely branded as pernicious and prevalent a poison as nicotine or mercury.

Magnesium is not in the detailed index of this exhaustive review, with over 600 references from standard medical research, sold by  and Barnes & Noble:
Rich Murray: Roberts: "Aspartame Disease" 1038 page expert magnum opus 7.5.1 rmforall
RTM: Newman & Lipton:
aspartame triggers & worsens migraine 11.17.1 rmforall
Headache 2001 Oct;41(9):899-901
Migraine MLT-Down: An Unusual Presentation of Migraine in Patients With Aspartame-Triggered Headaches.
[Merck 10-mg Maxalt-MLT, for migraine, has 4 mg aspartame.]
Newman LC, Lipton RB.
Headache Institute, St. Lukes-Roosevelt Hospital Center, New York
NY Department of Neurology
Albert Einstein College of Medicine, Bronx, NY
Innovative Medical Research
Rich Murray: Smith: fibromyalgia & aspartame & MSG 6.27.1 rmforall
Ann Pharmacother 2001 Jun;35(6):702-6
Relief of fibromyalgia symptoms following
discontinuation of dietary excitotoxins.
Smith JD, Terpening CM, Schmidt SO, Gums JG.
Malcolm Randall Veterans Affairs Medical Center, Gainesville, FL, USA.

Excellent 5-page review by H.J. Roberts in "Townsend Letter",
Jan 2000,  "Aspartame (NutraSweet) Addiction"
H.J. Roberts, M.D.
Sunshine Sentinel Press  P.O.Box 17799  West Palm Beach, FL 33416
800-814-9800 561-588-7628 561-547-8008 fax
WebMD: Barclay: Barth:
survey shows aspartame hurts memory in students 11.9.00
Timothy M. Barth Department of Psychology
Texas Christian University TCU Box 298920 Fort Worth, TX 76129
Chairman, Physiological Psychology   817-921-7410
Rich Murray: Karikas: aspartame binding to DNA:
Clinical Biochemistry July 1998 7.27.1 rmforall
Karikas GA, Schulpis KH, Reclos GJ, Kokotos G.
Dept. of Chemistry, University of Athens, Greece
Measurement of molecular interaction of aspartame and
its metabolites with DNA. Clin Biochem. 1998 Jul;31(5):405-7.

A radioactive tracer study proves that the methanol from a low dose of of aspartame binds formaldehyde, a deadly cumulative poison, into tissues:  Trocho C et al, June 26 1998, Life Sci, 63(5), 337-349.

Two teams find hot aspartame releases DKP, a potent carcinogen:
Food Addit Contam 2000 Oct; 17(10): 821-7
Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system.
Lin SY, Cheng YD
Biopharmaceutics Laboratory,
Department of Medical Research & Education
Veterans General Hospital-Taipei, Shih-Pai, Taiwan,
Republic of China.
J Pharm Sci 1998 Apr; 87(4): 508-13
Hydration and dehydration behavior of aspartame hemihydrate.
Leung SS, Padden BE, Munson EJ, Grant DJ
Department of Pharmaceutics, College of Pharmacy,
University of Minnesota, Minneapolis 55455-0343, USA.
Sophie S. Leung, PhD
Dolores J. Grant, PhD

Lennart Hardell, M.D., PhD, in 1999 reported in Sweden that both cell phone use and heavy aspartame use correlate with increased brain cancers   +46 19 602 15 46
is maintained by:  Paul Mason
P.O. Box 1417
Patterson, CA 95363

[Three books cover international symposia in 1976, 1988, and 2000. As it happens, there are a number of Greek researchers.]
Magnesium Research
Keep updated with the latest research in Magnesium

Magnesium Research is the official journal of the Society for the Development of Research on Magnesium--SDRM. It is the only journal in its field that is truly international and interdisciplinary. Magnesium Research is published in English and each article includes a summary in French. There is one volume comprising four issues per year.

Contents of forthcoming issue: Volume 14 number 3 June 2001
Editorial J. Durlach
Original articles: Experimental papers
Mechanisms of action of the anti-atherogenic effect of Mg:
Lessons for a mouse model.
Y. Sherer, R. Bitzur, H. Cohen, A. Shaish, D. Varor,
Y. Shoenfeld and D. Harats* (*tel-Hashomer, Israel)
Mg deficiency-induced anorexia in hyperphagic obese Zucker rats.
W. Rattanatayarom, C. Dormeister, U.G. Classen, H.F. Schimatschek, U.
Stein and H. G. Classen* (*Hohenheim-Stuttgart, Germany)
The effect of oral aspartame administration
on the balance of Mg in the rat.
L. Kovatsi and M. Tsouggas (Thessaloniki, Greece)
The effect of Mg deficiency in the rat on volatile anesthesic
requirements. The role of central noradrenergic activity.
L. Thomas, M. W. Crawford, M. Shams, R. Gow and F. J. Carmicael
(Calgary, Alberta, Canada)
Characteristics of improved NOVA Mg ion-selective electrode: changes of ionized Mg values and reference interval in healthy children
K. Hoshino*, K. Ogawa, T. Hishitani and R. Kitazawa (*Saitama, Japan)
Clinical papers
Dietary intakes of Mg, Ca and P by Polish adults.
K. A. Skibniewska (Olsztyn, Poland)
New data on the emchanisms of hypermagnesium in type 1 diabetes mellitus.
M.S. Djurhus (Odense, Denmark)
Letter to the editor
Serum Mg and Ca in patients with dorsalgiaes.
L. Steidl, R. Ditmar and A. Dostal (Olomouc, Czech Republic)
Commentary on therapeutical advances
Tocolysis, B mimetics and Mg: are true or false friends? J. Durlach
(Paris, France)
A triple-risk model for the sudden infant death syndrome (SIDS) and the apparent life-threatening episode (ALTE): the stressed magnesium deficient weaning  rat.
 J.L. Caddell (Philadelphia, PA, USA)
Abstracts: BIUL, Magnezol, 1000 5, (4) Calendar of Magnesium meetings.
ISSN 0953-1424
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Advances in Magnesium Research: Nutrition and Health
Editors Yves Rayssiguier, André Mazur and Jean Durlach
A valuable source of information and research
This comprehensive treatise by international authorities will provide a major reference for all those interested in any aspect of magnesium.

Magnesium plays an essential role in a wide range of fundamental cellular reactions. Hence it is not surprising that deficiency in the organism or disturbances of magnesium homeostasis may lead to serious biochemical and symptomatic changes. Recent surveys in industrialised countries suggest that a significant number of people consume less than international dietary reference intakes and there is emerging evidence that habitually low intakes of Mg are associated with etiologic factors in various metabolic diseases.

This book is the edited proceedings of Mag2000 the 9th International Magnesium Symposium organised with the assistance of the National Institute of   Agricultural Research (INRA), held in Vichy (France), September 2000. The meeting provided a forum to present recent advances on the functional role and metabolism of magnesium, and applications in the fields of nutrition, medicine and agriculture. The contributions cover a broad spectrum of material from the total organism through individual organ systems and down to the cellular, subcellular and molecular levels. The book comprises the reports from basic and clinical scientists who have been selected because of their recognised expertise and also original voluntary papers. International leaders in the field of magnesium have accepted to express their views not only on the major results obtained in the past years but also by pointing out new directions.

Magnesium research is rapidly moving and it is clear that in the next few years of the millennium there will be many advances in understanding the role of magnesium.

This book will help to stimulate research and encourage progress in this advancing field.

Contents: Section Headings:
Cellular magnesium: intracellular homeostasis and membrane transport; Magnesium and cell functions; Magnesium absorption and metabolism; Magnesium  and the kidney; Epidemiology of magnesium deficiency and recommended dietary allowance; Magnesium and water; Analytical aspects and assessment of magnesium status; Magnesium, inflammation and immunity; Magnesium and cardiovascular disease; Magnesium and endocrinology; Magnesium, osteoporosis and gynaecology; Magnesium and neuroscience; Magnesium and sports; Pharmacological uses of magnesium; Magnesium, animal health and agriculture; Indexes.
ISBN 0 86196 609 0     Paperback     September 2001     Price £75/US$131

Magnesium Deficiency: Physiopathology and Treatment Implications
by M.J. Halpern, J. Durlach (Editor).

Magnesium Deficiency in the Pathogenesis of Disease: Early Roots of Cardiovascular, Skeletal, and Renal Abnormalities (Topics in Bone and Mineral)  by Mildred S. Seelig.

Magnesium and the Cell
by Nicholas J. Birch (Editor)
Focuses on the molecular and biochemical aspects of magnesium in the cell that relate to its regulatory role. Three distinct audiences are addressed: biochemists and pharmacologists studying the processes in which magnesium has a pivotal role; clinicians who recognize that magnesium deficiency, as well as that of  potassium, is associated with several conditions; and researchers investigating the role of metal ions in the regulation of biological processes, or the role of  biomolecular interactions in cellular signalling and control. Annotation copyright Book News, Inc. Portland, OR.

Heart Healthy Magnesium: your nutritional key to cardiovascular wellness

by James B. Pierce, Ph.D.
Do you suffer from high blood pressure, irregular heartbeat, or chest pains? Do you get unexplained cramps or pains in your legs or back? Do you have trouble keeping your hands and feet warm? Has your doctor told you that you may be at risk for heart attack or stroke? If your answer is "yes, "you may be surprised to learn that a deficiency of one simple mineral - magnesium -- may be at the root of your problem. In Heart Healthy Magnesium, author James B. Pierce, Ph.D., explains how a surprising array of health problems - from insomnia, fading memory, and stiff, aching muscles, all the way to high blood pressure, arrhythmia, angina, heart attack, and stroke - may all be related to inadequate levels of magnesium in the body's muscle cells. Using clear non-technical language, Dr. Pierce explains the ways in which magnesium works to maintain the healthy functioning of the body as a whole, and of the cardiovascular system in particular. He discusses why and how magnesium deficiencies develop, how to know whether you are one of the many people affected by this condition, and what can happen when the body becomes starved for this essential mineral. Most important, he tells about the remarkable results that have been attained by using magnesium to promote heart health, and relates his own personal experience with cardiovascular disease. Dr. Pierce gives easy-to-follow guidelines for developing your own comprehensive and personalized nutritional program, including up-to-date information on diet, exercise, and stress reduction. Heart Healthy Magnesium provides an accurate account of the breakthrough scientific research that is now underway. It offers an approach to cardiovascular wellness that involves no costly drugs and no undesirable side effects - just a simple, safe, and effective program that can help you feel better than you have in years.

Phosphate and Mineral Homeostasis
(Advances in Experimental Medicine and Biology, Vol 208)
by Shaul G. Massry, Michel Olmer, Eberhard Ritz

Mg 2+ and Excitable Membranes
by P. Strata, E. Carbowe (Editor) REVIEWS

Metal Ions in Biological Systems
by Helmut Sigel, Astrid Sigel (Editor)

Magnesium in Cellular Processes and Medicine
by B.M. Altura, J. Durlach, M.S. Seelig (Editor)

Magnesium in Biological Systems: Environmental and Biomedical Aspects
by T. Fazekas, B. Selmiczi, P. Stefanovits (Editor)

Magnesium and the Cell
by Nicholas J. Birch (Editor)

Focuses on the molecular and biochemical aspects of magnesium in the cell that relate to its regulatory role. Three distinct audiences are addressed: biochemists and pharmacologists studying the processes in which magnesium has a pivotal role; clinicians who recognize that magnesium deficiency, as well as that of potassium, is associated with several conditions; and researchers investigating the role of metal ions in the regulation of biological processes, or the role of biomolecular interactions in cellular signalling and
control. Annotation copyright Book News, Inc. Portland, OR.

Magnesium: Current Status and New Developments: Theoretical, Biological, and Medical Aspects
by Theophile Theophanides (Editor), Jane Anastassopoulou (Editor)

This volume contains the Proceeding of the 8th International Symposium on Magnesium. It presents research and applications in order to interface between medical doctors, clinicians and scientists responsible for magnesium involvement in the pathogenesis of diseases, its biological significance, metabolism and many other utilizations which are associated with membranes and cells. The topics which are discussed concern mechanisms of the mode of action of free magnesium  cations, hydrated cations and magnesium-linked cations.

The Biological Chemistry of Magnesium
by J. A. Cowan (Editor)
Emphasizing interactions at the molecular level, reviews the current understanding of magnesium biochemistry, especially the pivoltal role of magnesium ion in nucleic acid biochemistry. The topics include magnesium as the catalytic center of RNA enzymes, magnesium-dependent enzymes in the general metabolism, the genetics and molecular biology of magnesium transport systems, and the regulation of cytosolic magnesium ion in the heart. Addressed to graduate students and non-specialists in biochemistry, biotechnology, pharmaceutical sciences, and related disciplines. Annotation copyright Book News, Inc. Portland, OR.

Calcium and Magnesium Metabolism in Early Life
by Reginald C. Tsang (Editor)

Magnesium in health and disease: Fifth International Magnesium
Symposium, August 8-12, 1988, Kyoto, Japan

Magnesium in health and disease: proceedings of the 2nd International
Symposium on Magnesium, Montreal, Quebec, May 30-June 1, 1976

Crazy Water:The Story of Mineral Wells and Other Texas Health Resorts
By Gene Fowler
Author Gene Fowler tells how the FDA destroyed the American mineral water industry in the 1930's, taking magnesium away from consumers.

Rich Murray, MA    Room For All
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