Omega-3 Fatty Acids from Flaxseed Oil for Bipolar Disorder (Manic Depression)




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"The doctor of the future will give no medicine, but will interest his patients in the care of the human frame, in diet and in the cause and prevention of disease."
- Thomas Edison

Omega 3 fatty acid (vitamin F) is an important part of our anti-cancer program and brings many other health benefits as well.

Omega 3 fatty acid (vitamin F) may be an alternative to Ritalin for ADD/ADHD. This is important because Ritalin may cause cancer.

Monitor your body composition with the Tanita Body Composition Monitor.


April 1 2001

Rich Murray: Stoll: Omega-3 fatty acids from flaxseed oil for bipolar disorder May 1999 book: "The Omega-3 Connection" 2001:
WWW activity: CABF 4.1.1 rmforall

Rich Murray  Room For All
1943 Otowi Road   Santa Fe  NM 87505

"With a prevalence of 1.0% the U.S. population, bipolar disorder is a debilitating psychiatric condition associated with severe morbidity, even mortality."  [3 million people!]

Herein  I summarize  research and a book by Andrew  L. Stoll, how much it is mentioned on the Net, the amazing number of support groups, and the outstanding patient advocacy group CABF, a model that many may well emulate:

Prostaglandins Leukot Essent Fatty Acids
1999  May-Jun;60(5-6):329-37
Omega-3 fatty acids and bipolar disorder: a review.
Stoll AL, Locke CA, Marangell LB, Severus WE
Psychopharmacology Research Laboratory,
McLean Hospital, Belmont, MA 02478, USA.

The important role of the omega-3 fatty acids in the pathophysiology and treatment of bipolar disorder is now supported by a substantial body of indirect and direct evidence. This paper will describe the clinical and pharmacological features of bipolar disorder, review the available data regarding omega-3 fatty acids in bipolar disorder and provide recommendations for future research.   Publication Types: Review   Review, tutorial PMID: 10471117

Arch Gen Psychiatry 1999 May;56(5):407-12
Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial.
Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB [Andrew L. Stoll, MD; W. Emanuel Severus, MD, PhD; Marlene P. Freeman, MD; Stephanie Rueter; Holly A. Zboyan; Eli Diamond; Kimberly K. Cress, MD; Lauren B. Marangell, MD]
Brigham and Women's Hospital, Department of Psychiatry
Harvard Medical School, Boston,
Mass, USA.

Full text at

BACKGROUND: Omega3 fatty acids may inhibit neuronal signal transduction pathways in a manner similar to that of lithium carbonate and valproate, 2 effective treatments for bipolar disorder. The present study was performed to examine whether omega3 fatty acids also exhibit mood-stabilizing properties in bipolar disorder. 
METHODS: A 4-month, double-blind, placebo-controlled study, comparing omega3 fatty acids (9.6 g/d) vs placebo (olive oil), in addition to usual treatment, in 30 patients with bipolar disorder.
RESULTS: A Kaplan-Meier survival analysis of the cohort found that the omega3 fatty acid patient group had a significantly longer period of remission than the placebo group (P = .002; Mantel-Cox). In addition, for nearly every other outcome measure, the omega3 fatty acid group performed better than the placebo group.
CONCLUSION: Omega3 fatty acids were well tolerated and improved the short-term course of illness in this preliminary study of patients with bipolar disorder. 
Publication Types: Clinical trial  Randomized controlled trial
Comment in:   Arch Gen Psychiatry. 1999 May;56(5):413-6
Arch Gen Psychiatry. 2000 Jul;57(7):715
Arch Gen Psychiatry. 2000 Jul;57(7):716-7
PMID: 10232294

Andrew Lawrence Stoll M.D.  Assistant Professor of Psychiatry
Department:   Psychiatry Consolidated        McLean Hospital
115 Mill St.       Nb 303       Belmont, MA 02478
(617) 855-2459         Fax:    (617) 855-3619
************************************************   The Winds of Change
Bipolar Disorder Support Group
The Winds of Change, Inc., P.O. Box 251453
Plano, TX 75025-1453, Phone: 972-312-7772
with  Kimberly Bailey & Marcia Purse   extensive links &
details on drug side effects   allergy to
milk products  and high-gluten foods (like wheat, barley, and rye)
13 Sep 2000 by LyndaNP - View Thread
1999 American Psychiatric Association Annual Meeting
Day 4 - May 20, 1999
General Guidelines and Intricacies in the Treatment of Bipolar Disorder
Frederick K. Goodwin, MD    Writer: Tracey L. Irvin, MD

Each psychiatrist should have a dietitian with whom they can consult on strategies for maintaining a diet low in simple carbohydrates in order to stabilize blood sugar. Patients with bipolar disorder tend to have unstable blood sugars, and many of the symptoms of hypoglycemia can be confused with those of the illness, or with side effects of the medication. In addition, patients should be encouraged to reduce their caffeine intake. Caffeine has the tendency to reduce the quality of sleep. This begins a vicious cycle in which decreased sleep quality leads to decreased daytime energy, leading to higher caffeine use.

Subject:   Re: Rich Murray: Stoll: Omega-3 fatty acids from
flaxseed oil for bipolar disorder May 1999
         3.28.1 rmforall
     Date:   Thu, 29 Mar 2001 00:02:47 -0500
     From:   "Andrew L. Stoll, M.D." <>
       To:     Rich Murray <>

Thanks for the information and for quoting our studies. We continue to be very excited about omega-3 fatty acids in various psychiatric disorders, particularly in depression and bipolar disorder. By the way, I have just published a book for the sophisticated lay audience as well as clinicians on omega-3s and psychiatry. It is called The Omega-3 Connection (Simon and Schuster 2001), and I think it is available just about everywhere. Thanks again.

-Andrew L. Stoll, M.D.

April 1 2001   Hello Andrew L. Stoll,   I was glad to get your appreciative reply. I know how busy researchers are. I found four very positive reviews of your book on .

Searched  "Andrew Stoll" on , which searches the last six months of all news discussion groups: 14 listed items:  None mention your book!

a very positive, complete short article:
Friday, 14 May, 1999, 17:31 GMT 18:31 UK
Scientists back nature's anti-depressants
"Fish Oil Supplements Help Manic Depression
NEW YORK, May 13 (Reuters Health) -- Daily supplements of fish oil may help control the 'mood swings' of patients with bipolar disorder (manic depression), according to researchers.
Fish Oil May Help Control Bipolar Disorder
By Peter J. Howe, The Boston Globe

From: mcman (
Subject: Omega-3
Date: 2000-08-31 10:25:49 PST
While I was at the National Depressive and Manic Depressive Conference in Boston, I attended Dr Andrew Stoll's session on omega-3, which I've featured in my latest Depression and Bipolar Weekly. Also: juvenile mania, acupuncture, tragedy in Toronto, a possible Kay Jamison movie starring Julia Roberts, and more. For your free online subscription, please go here:

This post presents your entire report!:
From: LyndaNP (
Subject: Re: (Omega 3 Fatty Acids): Herbs & Supplements: Fish Oil
Date: 2001-02-18 09:38:07 PST
kathleen <> wrote:
My doc believes strongly in flaxseed oil and prescribes it for many of his  patients, including me.  I take 2 Tbsp per day, with an orange juice chaser, and do not have any problems with the taste or aftereffects.  He told me there was an article on its psychiatric and other effects in the Journal of AMA -- if anyone is interested I can ask him for the exact reference. I can tell the difference when I don't take it -- it seems to act as a mood stabilizer for me.

Hi again Kathleen,

Here is the original study conducted by Dr. Andrew Stoll et al.  also
take Flaxseed oil as well :).

Peace,  Lynda

A positive comment:
What are some of the good doctors up there at Mclean for treatment resistant depression? Andrew Stoll is best known for the omega-3 fatty acids research he's done, but he's also supposed to be a very good psychopharm in general. (He isn't generally biased toward "herbal" treatments, although he has been very impressed with the results he's gotten from omega-3's.)

Lynda gives long reports on Paul Keck, Gary Sach, Paul Janicek,
Andrew Stoll:
 From: LyndaNP (
 Subject: APA: New Med Info
 Date: 2000-08-31 05:43:40 PST
1999 American Psychiatric Association Annual Meeting
Day 2 - May 18, 1999
Medication Controversies in the Treatment of Bipolar Disorder
Jerrold F. Rosenbaum, MD  Writer: Steffany Fredman, BA
"Bipolar Disorder is common, deadly, and treatable." These words, by Gary Sachs, M.D., of the Massachusetts General Hospital, capture the nature of this illness and the challenge facing psychiatrists who treat it. With a prevalence of 1.0% the U.S. population, bipolar disorder is a debilitating psychiatric condition associated with severe morbidity, even mortality.

As discussed at a symposium entitled, "Medication Controversies in Bipolar Disorder," held Tuesday, May 18, 1999 at the 152nd Annual Meeting of the American Psychiatric Association, one of the biggest dilemmas facing clinicians is how to choose among the many agents used to treat bipolar disorder, few of which have actually been empirically tested with randomized, controlled trials.

mentions Andrew Stoll, Malcolm Peet, Joseph Hebbln:
From: Leslie J. (
Subject: Re: Fish Oil for BP
Date: 2000-08-28 11:40:35 PST


Google WWW search  "The Omega-3 Connection":
about 35 listed  items, mostly merchants, about your book:

An enthusiastic advertisement:
Dr. Stoll believes that more than 70,000 lives could be saved each year in the United States alone if Americans had sufficient omega-3 oils in their bodies. He marshals the evidence that omega-3 oils (which are most commonly found in cold-water fish) are a positive juggernaut for supporting cardiovascular health (see Omega-3 Fish Oils Promote Cardiovascular Health - Jun. 1999). Not only do they help prevent arterial plaque formation and blood clotting, but they also help to guard against cardiac arrhythmias and reduce the incidence of ischemia (insufficient blood flow to the tissues).

Moreover, there is evidence that omega-3 fish oils can directly benefit certain muscle cells of the heart, protect the kidneys, alleviate rheumatoid arthritis, abate inflammatory bowel diseases, reduce episodes of transplant rejection, provide protection from infection, and even sharpen cognitive function. All of this is skillfully presented in Dr. Stoll's fine book.

Dr. Stoll is not given to hyperbole. On the contrary, this Harvard Medical School doctor is thoughtful, methodical, philosophically wise, and insightful. As well, he is the author of a pace-setting study that we reported on in Omega-3 Fish Oil for Mood Swings - Jul. 1999......

Doesn't mention Andrew Stoll:
NZHIAI   New Zealand Hemp Industries Assc., Inc.
Brain Function and Omega-3s   by David  J. Musgrave
Waihi Bush Organic Farm, 21 RD, Geraldine.
Phone Tollfree: 0508 4 WAIHI (0508 492 444)

In a previous article in this Journal
(Brain Development - The Omega-3 Connection in Early Childhood)
I focused on the need for large amounts of Omega-3 Essential Fatty Acids (EFAs) for normal brain development of the foetus and new born infant. I also discussed the potential effects of Omega-3 deficiency on the incidence of learning disorders such as dyslexia and Attention Deficit Disorder/ Attention Deficit and Hyperactivity Disorder (ADD/ADHD). Also considered was the potential for post natal depression in the mother as a consequence of the baby's demand for Omega-3 from her, both in utero and while breast feeding. EFA function and sources were briefly explained for those not familiar with this subject. In this current article I would like to extend the discussion of the Omega-3 connection to problems with brain function in later life......

Many sites and groups support Omega-3 for ADHD:   Gluten Free Casein Free Diet    has 1868 members, an astonishing number,  and a total of 62,923 posts in their fully searchable archive, about 100 daily.    Searched  "bipolar" to find 266 free, fully archived, searchable discussion groups, with 19 larger ones, 90 to 242 members each.

Typical is with 158 members and 10-20 daily posts, one of 10 large groups sponsored by an outstandingly well-organized patient advocate network: CABF.

All patient advocate networks would do well to study this site:
Child &  Adolescent Bipolar Foundation
1187 Wilmette Ave.,  P.M.B. #331, Wilmette, IL 60091
Voice: (847) 256-8525     Fax: (847) 920-9498
CABF President's Welcome 2001
Welcome to CABF! We are a community of people who care about children and adolescents with bipolar disorders (manic-depressive illness). It is my pleasure to introduce you to all the wonderful resources you will find here, as well as to the warm and meaningful support we provide one another. Whether you are a parent, family member, friend, young person, educator, or health professional, I encourage you to make yourself at home and explore our community center!

Here at the Front Desk, you can learn about the Child & Adolescent Bipolar Foundation, including our mission and goals. You can also become a member, sponsor, or donor, see a map of the entire web site, and peruse the calendar of upcoming events. Your next stop might be the Learning Center, with its many articles on early-onset bipolar disorder, research findings, and interviews. This is the place to begin or augment your understanding of this serious but treatable medical illness.

The heart of CABF is the Community Center. Here you will find message boards, chat rooms, and on-line support groups that will connect you with others in similar circumstances. End isolation and make new friends as you share information and support in an atmosphere of respect and understanding. The Community Center also features an on-line searchable database of professionals, a fine arts gallery of works by our bright and creative children, a listing of research studies, and a bookstore.

Visiting the Resource Center of our community will provide you with essential resources (such as Social Security Disability information and a directory of in-person support groups) right on the CABF Web site. It also features links to many other useful Web sites. You can meet the Board of Directors, Professional Advisory Board, staff, and team leaders when you visit CABF People. We are real people who began our journey in much the same way you have, and we value your insights. If you would like to get involved in CABF, click on CABF Teams.

I hope this short introductory tour gives you an idea of our commitment to young people and their families living with bipolar disorders. With proper treatment and support, our children will thrive and be able to give their many gifts to the world. I invite you to get comfortable, get acquainted, stay as long as you like, and visit often!

Wishing you health and peace,       Ruth Field,   President
The Child & Adolescent Bipolar Foundation's (CABF's) "virtual community center" offers the following:

Learning Center with full-text medical journal articles and extensive original educational content developed for parents by CABF and approved by CABF's 14-member professional advisory board; 12 Message Boards on topics such as education, treatment, doctors and hospitals, good news stories, news and announcements, support groups forming, resources for kids, and more; Bookstore and Gallery of Children's Art and Poetry; 20 On-Line Support Groups (including BPParents) with over 1,700 families participating; Chat Rooms open day and night; Searchable database of professionals and local support groups; Resources page with links to government sites on Social Security, Insure Kids Now, Medicaid, a Drug Database, and International Resources (for visitors from over 50 countries).
The Omega-3 Connection, by Andrew L. Stoll, M.D., (Simon & Shuster, New York, 2001). Depression and schizophrenia are worse in countries where people eat a Western diet.....
CABF eBulletin   quarterly
Newsletter of the Child & Adolescent Bipolar Foundation

This attractive newsletter is created using software and services from for ten cents a subscriber per month:
1254 Chestnut Street   Newton, MA 02464
Researchers and families-a promising alliance
Monday, February 26, 2001
An editorial by Martha Hellander, CABF Executive Director

My position in CABF provides a fascinating perspective upon two vastly different worlds: that of families raising children with bipolar disorder, and that of scientific researchers who study them. Sometimes it seems that a Berlin Wall divides us.

Riveting and informative stories fill our Web site message boards daily.

How anyone can watch "Survivor" and ignore the gripping dramas played out on our site is beyond me. Since we launched just over a year ago, the lives of families are an open book, available to any student of bipolar illness in children who cares to read them. At least one medical school, to its credit, makes CABF's Web site required reading for its residents in child psychiatry. We have yet, however, to find any takers in the scientific community willing to help us properly collect and analyze the on-line parent reports of treatment successes and adverse drug events that pour into our site, raw and messy and filled with noisy contradictions, like life itself.....
**********************************************   excellent diet info       dairy toxicity       aspartame toxicity    MSG toxicity   soy toxicity   Mary J. Shomon    fluoride toxicity   junk science   Moyers on chemicals


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