June 19, 2006
For the month of June,
Baseline Nutritionals is celebrating the
incredible results of the Glucotor Phase I clinicals with a
special. They're giving away a free bottle of their best
selling, industry standard Digestive Enzyme
formula with any order that contains 3 or more bottles of
And now Jon.
Cancer and Your Immune System
I have maintained for years that cancer is fundamentally a
disease of the immune system. It takes root when your exposure
to contaminants gets too high, or the strength of your immune
system drops too low. And after years of crying in the
wilderness (there were actually a few of us), it's finally nice
to get a little confirmation from the medical establishment. In
May 2006, the concept of the immune system as the body's primary
natural defense system against cancer reverberated around the
world with the release of a story about a mouse -- ultimately,
surprising researchers and reinforcing my theory.
Three Blind Mice
Part III of an ongoing study titled
Transferable anticancer innate immunity in spontaneous
regression/complete resistance mice was published in
the May 8, 2006, issue of The Proceedings of the National
Academy of Sciences (PNAS). This report highlighted the
latest in the remarkable ongoing study that started with the
discovery of a strain of cancer resistant mouse. These latest
results from a Cancer Research Institute (CRI) funded study
at Wake Forest University School of Medicine show that
this genetic resistance to highly aggressive cancers can be
transferred from a strain of cancer-resistant mice into ordinary
mice, causing complete destruction of large tumors and life-long
protection against future tumor growth. What surprised
researchers was the fact that this resistance is based on
innate immunity to cancer rather than adaptive immunity
(based on T and B cells).
- Innate immunity is what we are born with and it
is nonspecific; all antigens are attacked pretty much
equally. It is genetically based, and we pass it on to our
- Adaptive immunity (also referred to as learned
or acquired immunity) is, on the other hand, characterized
by specific immune responses to an antigen. In other words,
with adaptive immunity, you have no defense for a virus or
bacteria until you've been exposed to that particular virus
or bacteria -- or one very much like it and learned how to
defend against it.
What's exciting about these results is that the mice outside
of the unique cancer resistant gene pool were cured. In fact
these studies show that specific types of innate immune cells,
such as macrophages, can migrate to the site of cancer in a
normal mouse and selectively kill all of the cancer cells
without harming normal cells. Not only were the white blood
cells able to find the cancer (indicating a signaling
relationship) the cancer immunity appeared to last for the
lifetime of the injected mice.
What is Transferred Immunity?
Specifically, what was done was that white blood cells from a
family of established spontaneous/cancer resistant strain of
mice that possessed the unique gene referenced above were
injected into normal mice that did not possess this gene in an
attempt to transfer this unique immunity to normal mice.
Challenging the Initial Results
Even when the researchers' own in vitro (test tube)
experiments clearly suggested that the innate immune
cells themselves were responsible for tumor killing,
these stunned scientists searched for another explanation by
performing "challenge experiments".
Researchers placed cancer cells and immune cells from
spontaneous remission/cancer resistant (SR/CR) mice together in
a normal mouse to determine whether the cancer cells could
survive. Without the SR/CR immune cells, such cancers grow
rapidly in normal mice and the mice die in 3-4 weeks.
Results -- the tumors were selectively
killed! While these results strongly suggested that no other
cell type or soluble factor in the mice was required to allow
the immune cells to function and kill cancer, researchers
continued to challenge this unexpected result.
Researchers injected a normal mouse with cancer cells and
allowed the tumor to implant and grow, then injected the SR/CR
immune cells at a later time.
Results -- the tumors were selectively
killed! Still not convinced, the researchers devised a third
Researchers injected the normal mice with cancer cells at one
site (e.g., below the skin on the back), and then later injected
the SR/CR immune cells at another site (e.g., into the abdomen).
This meant that the injected immune cells would have to migrate
to the tumor and kill it at a distant site, all the while being
in a normal mouse tissue environment. Researchers injected other
mice with similar immune cells from a normal non-resistant
strain of mouse to serve as controls.
Results -- The SR/CR injected mice showed an
initial swelling at the tumor site, a response that researchers
felt indicated an influx of active white blood cells into the
tumor. Two weeks later, the cancers had completely disappeared.
As you might now expect, the control mice showed no tumor
shrinkage and eventually died. What was unexpected was
that in the SR/CR injected mice tumors never came back even
after a period equal to half the mouse life span.
According to researchers, "Activation requires no prior
exposure, but rather depends on a pre-determined mechanism to
recognize specific patterns on the cancer cell surface."
What is the Importance of the Study?
- Establishes the "potential" of transferring cancer
immunity into all human beings
- Establishes the potential for life long protection
- Reinforces the theory I proposed a number of years ago
about cancer being a disease of the immune system
Establishes the Potential of Transferring Cancer Immunity
While these experiments serve as an example of immunity
transfer potential in live human beings, you should know that
the donor and recipient mice were both in the same in-bred
laboratory strains of mice. Put simply, except for the SR/CR
mutation, the mice are genetically identical. This means that
the results may be due in part from a suspected inclusion of
stem cells in the white blood cell injection. In other words,
duplication of these results in biologically unrelated humans
might be tricky at best.
Establishes Possibility of Long Term Protection
By performing these challenge experiments using immune cells
from a male SR/CR mouse and transferring them into a female
recipient normal mouse, the injected immune cells could be
identified later because the injected immune cells contained a
"y" chromosome. "In this way, we were able to show that some of
the injected immune cells survived for a very long time and were
probably involved directly in killing the distant cancer".
Reinforces the Cancer/Immune System Link
The bottom line is that this study strongly supports, right
now today, the theory I proposed some years ago that cancer is
fundamentally a disease of the immune system -- and, by
extension, effectively supports the recommendations I made at
the same time for preventing and dealing with cancer, if you get
it. What do I mean by that?
Why Most People Don't Get Cancer
Quite simply, in your body, as part of the normal metabolic
process, you produce anywhere from a few hundred to as many as
10,000 cancerous cells each and every day of your life. If your
immune system is functioning properly, it has the ability to
recognize each and every one of those aberrant cells and remove
them from your body. The reason that everybody doesn't get
cancer is because their immune systems are designed to prevent
it. That's just what a healthy immune system does. In effect,
every one of us starts with a hint of that innate cancer
immunity that the special strain of mice demonstrates.
According to the National Cancer Institute's (NCI)'s
description of cancer and immunity, when normal cells turn
into cancer cells, some of the antigens on their surface change.
These cells, like many body cells, constantly shed bits of
protein from their surface into the circulatory system. Often,
tumor antigens are among the shed proteins. These shed antigens
prompt action from immune defenders, including cytotoxic T
cells, natural killer cells, and macrophages.
NCI explains one theory. Patrolling cells of the immune
system provide continuous body wide surveillance, catching and
eliminating cells that undergo malignant transformation. Tumors
develop when this immune surveillance breaks down or is
Your Cancer Surveillance System
Part II of the mouse study cited above, researchers said
that this unique mouse (and subsequent offspring) have provided
another bit of evidence that immune surveillance is probably a
normal process that protects us from developing cancer. In fact,
immune surveillance suggests that as cancer cells develop, they
are detected by the immune system at a very early stage (perhaps
at the stage of a single cell or a few cells) and are then
killed and cleared from the body. But again, this happens only
if your immune system is functioning properly.
The researchers effectively then restate my premise when they
say, "This concept [immune surveillance] implies that we are
constantly getting cancer (one cell at a time) but the cancer
cells do not survive because our immune systems detect and kill
them. But only the cancer cells die; normal cells are unharmed."
To clearly illustrate that immune cells attack cancer cells,
I offer the following picture from the above referenced study in
which you can see first hand the immune system at work on cancer
cells just hours after the SR/CR injection.
Through their experiences with this unique family of mice,
researchers pose the question, "Could it be that we constantly
reject cancer cells by immune surveillance throughout our lives
and, as we age, that mechanism becomes weaker and weaker, until
finally one cancer cell overcomes those controls?" Well, it's
nice to see that even if they are 10 years behind, they're at
least starting to come around to the obvious. But as it turns
out, only so far. They still want to turn their understanding of
the relationship of the immune system and cancer into a possible
future magic bullet -- not an immediate means to prevent 90% of
all cancers. So let me fill in where the researchers left off.
Why People Get Cancer
People get cancer because one of three things happens (and
more often than not all three together):
- You expose yourself to toxins and outside influences
(such as heavy metals, radiation, rancid fats, viruses,
bacteria, parasites, etc.) that dramatically increase the
number of cancerous cells your body produces so that not
even a healthy immune system can handle the load.
- You compromise your immune system (or age takes a toll)
to the point that it can no longer handle all of the
cancerous cells your body produces, thus allowing some of
them to take root and establish themselves.
- Your circulation (blood, lymph, energy) is impeded
--thus leading to both 1 and 2 above.
Again, to repeat the core concept here. Every single day of
your life your body produces anywhere from a few hundred to as
many as 10,000 cancerous cells as part of it's normal metabolic
processes. That means no one, by definition, is ever cancer
free, ever. The difference is whether that cancer takes root and
grows, or is destroyed by your immune system. While the option
of a mouse inspired miracle immune cell injection may be a
future option for humans, it is not an option today. That leaves
you only one option available right now: to optimize the
immunity you already have.
One lesson we can learn from the mouse study that we can
implement today is that it is crucial for you to support the
functioning of your body's ever-aging natural immune
surveillance system. That is:
- Remove immunosuppressant contaminants
- As much as possible, avoid subjecting your body to
contaminants such as chlorine, cigarette smoke, smog,
radon gas, xenoestrogens, tap water, rancid fats, etc.
- Regularly clean out those contaminants that do make
it in by doing periodic detoxes and cleansings.
Specifically a rotating program of Intestinal Cleanses,
Heavy Metal Detoxes, Liver Cleanses, Blood Cleanses, and
- Regularly use natural pathogen destroyers such as
garlic, olive leaf extract, and oil of oregano to reduce
the bacterial, viral, and fungal load on your immune
- Use proteolytic enzymes to support your enzyme based
complementary immune system.
- Boost your existing immune function
- Use herbs such as Echinacea and Astragalus and
nutraceuticals such as AHCC and alkyglycerol to build
your immune system.
- Optimize circulation.
- Use a high quality proteolytic enzyme formula to
optimize blood flow.
- Exercise to improve lymph flow.
- Body work and
energy enhancement to improve energy flow and
cellular energy levels energy.
- Reduce stress through mediation, prayer, soaking in a
hot tub, or biofeedback.
- For the curious:
- Listen to my talk on
Cancer, The Big Lie, to get a better
understanding of this issue. Highly recommended.
Doing the Baseline of Health Program Intensively.
- Read the
- To learn more about the beginning of the ongoing
mouse study, you can read lead researcher, Zheng Cui's
personal account of the discovery of the SR/CR mice.
# # #
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